May 7, 2007

Eczema And Hay Fever May Be Falling After Rising In Recent Decades

After having risen year on year in recent decades, the rates of eczema and hay fever seem to have stabilised, and may even be falling, suggests research published ahead of print in Thorax.

But the rates of systemic allergic reactions, such as anaphylaxis and those related to food have soared, the data suggest.

The research team carried out a time trends analysis on the rates of illness and death for allergic disorders, excluding asthma.

They used national representative data and information from national surveys, consultations with primary care health practitioners, prescriptions, hospital admissions, and deaths.

Diagnoses of allergic rhinitis and eczema in children have trebled over the past three decades, but the prevalence of symptoms seems to have fallen recently.

Hospital admissions for eczema have also stabilised since 1995, while those for allergic rhinitis have fallen to about 40% of their 1990 levels.

Similarly, consultations with a family doctor for hay fever rose by 260%, and for eczema by 150%, between 1971 and 1991. But once again, rates have stabilised in the past decade, the figures indicate.

However, hospital admissions for anaphylaxis (serious allergic reaction in several areas of the body) have risen by 700%, those for food allergy by 500%, and those for the skin allergy urticaria by 100%.

Rates of angio-oedema, in which an absence of a specific protein promotes tissue swelling, leading to difficulties breathing, also rose by 40%.

Prescriptions for all types of allergy have also increased since 1991, the data show.

The findings suggest that while eczema and hay fever may have peaked, systemic allergies may be on the increase, say the authors.

They speculate that some of the trends could be explained by changes in medical practice and care, but they could also be attributable to changes in the sources of allergic disease.


Contact: Emma Dickinson
BMJ Specialty Journals

New Children's Claritin(R) Grape Chewables Provide Non-Jittery, Non-Drowsy, All Day Relief For Kids' Allergy Symptoms

Helping young kids relieve their allergies during the busy back-to-school season just got easier. Schering-Plough Corporation (NYSE: SGP) today announced the introduction of CHILDREN'S CLARITIN(R) Grape Chewables, a pleasant-tasting, convenient and easy-to-take form of CHILDREN'S CLARITIN that relieves kids' worst allergy symptoms without causing jitteriness or drowsiness so they can focus on their school work -- not their allergies.

Allergies affect up to 40 percent of American children (1), who miss about two million school days a year due to bothersome symptoms (2) such as itchy, watery eyes, sneezing, and a runny nose. Some allergy medicines are labeled to take every four to six hours, which may not cover the entire school day. Some may cause drowsiness or jitters, which may challenge the ability of young students to focus at school. CHILDREN'S CLARITIN Grape Chewables provide non- drowsy, non-jittery, all day relief while kids are at school so kids don't let allergy symptoms get in the way of doing their best work.

Nurse practitioner Regina Muccio, Pediatric Specialists of Foxborough and Wrentham, Mass., will now recommend CHILDREN'S CLARITIN Grape Chewables for the trusted relief of CLARITIN(R) allergy products that parents can rely on. "The chewable tablet is easy for kids to use, so all the medicine can go down easily every time," says Muccio.

CHILDREN'S CLARITIN Grape Chewables are safe for children ages two and up (3), and adds to the portfolio of CHILDREN'S CLARITIN formulations along with CHILDREN'S CLARITIN Fruit-flavored Syrup and Grape Syrup, introduced in 2005. CLARITIN(R) RediTabs(R) Tablets are approved for children ages 6 and up. Children who feel too old for syrup but not yet ready to use adult tablets now have an option that's just right.

CHILDREN'S CLARITIN Grape Chewables will be available at stores nationwide. For more information about CHILDREN'S CLARITIN visit


A pediatrician recommended brand, CHILDREN'S CLARITIN allergy products include CLARITIN Syrup, the first over-the-counter non-drowsy antihistamine safe for kids as young as two years of age. CLARITIN RediTabs Tablets is a once-daily tablet that melts instantly (4) in the mouth for children ages six and up. In 2003, the FDA approved CLARITIN Hives Relief(R)tablets as the first-ever indication for the OTC relief of itching due to hives, a common skin condition, for adults and children ages six and up.

About Schering-Plough

Schering-Plough Consumer Health Care is the U.S. over-the-counter (OTC) and consumer products business unit of Schering-Plough Corporation (NYSE: SGP), a global science-based health care company with leading prescription, consumer and animal health products. Through internal research and collaborations with partners, Schering-Plough discovers, develops, manufactures and markets advanced drug therapies to meet important medical needs. Schering-Plough's vision is to earn the trust of the physicians, patients and customers served by its more than 32,000 people around the world. The company is based in Kenilworth, N.J., and its Web site is


The information in this press release includes certain "forward-looking statements" within the meaning of the Securities Litigation Reform Act of 1995, including statements relating to CLARITIN allergy products and the potential market for CLARITIN allergy products. Forward-looking statements relate to expectations or forecasts of future events. Schering-Plough does not assume the obligation to update any forward- looking statement. Many factors could cause actual results to differ materially from Schering-Plough's forward-looking statements, including market forces, economic factors, product availability, patent and other intellectual property protection, current and future branded, generic or over-the-counter competition, the regulatory process, and any developments following regulatory approval, among other uncertainties. For further details about these and other factors that may impact the forward-looking statements, see Schering-Plough's Securities and Exchange Commission filings, including Item 1A. Risk Factors in the Company's second quarter 2006 10-Q.

(1) American Academy of Allergy, Asthma and Immunology. The Allergy Report. Vol. I. Rochester, NY: Academic Services Consortium, University of Rochester; 2000. 1.
(2) Meltzer EO. Quality of life in adults and children with allergic rhinitis. Mosby 2001. S49.
(3) When used as directed.
(4) Speed of dissolution does not imply speed of relief.

Are The Dangers Of Childhood Food Allergy Exaggerated?

Two child health experts go head to head in this week's BMJ over whether the dangers of childhood food allergy are exaggerated.

Professor Allan Colver from the University of Newcastle upon Tyne believes that the dangers are overstated, and that the increasing prescription of adrenaline injector kits fuels anxiety rather than saving lives.

Food allergy is often thought to be more dangerous and frightening than pneumonia, asthma, or diabetes, he writes. In reality, the risk of death is very small. Eight children under 16 years died from food allergy between 1990 and 2000 in the UK. That is one death per 16 million children each year. Yet childhood food allergy is being diagnosed more often and the number of prescribed adrenaline kits has greatly increased.

A diagnosis of food allergy creates much anxiety for all who care for the child, so it is important to get the diagnosis right, take sensible measures to reduce risk, and reassess regularly to check whether the child has grown out of their allergy, he says.

It is unclear what proportion of children with food allergy should be prescribed an adrenaline kit. The main argument in its favour is that reactions are best treated within a few minutes rather than waiting for medical assistance. But Colver suggests that they cause unnecessary anxiety, may not prevent death, and should be prescribed only when a diagnosis of food allergy has been confidently established.

The dangers of food allergies are not exaggerated, argues Professor Jonathan Hourihane from University College Cork, Ireland. Food allergy is common - 2% of adults and up to 6% of preschool children are affected and, although deaths are rare, other reactions are almost inevitable over time.

No tests are available to predict who will or will not have a severe allergic reaction, so management consists of empowering patients and providing rescue drugs. Delay in use of these drugs is associated with a worse outcome in severe reactions.

Proper management in allergy clinics means that most patients never have to use these drugs, but it is wrong to say that they are not needed, he says. Nobody is advocating "more general use" of adrenaline. What is advocated is increased availability of adrenaline kits for people who might need to use them. They should not be withheld because of the medical uncertainty surrounding allergy.

Food allergy is here to stay, he writes. The disease is a killer (though rarely); it can erode or inhibit normal formative experiences in childhood, and it impairs a child's quality of life. Let's get allergy services out of the academic centres and into the community, which is where food allergy is really "dangerous," he concludes.

Click here to view full paper:

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AERIUS Now Approved For Use In Intermittent And Persistent Allergic Rhinitis

Schering-Plough Corporation today announced the launch of two multinational clinical trials, and an important label change for AERIUS (desloratadine) in the European Union (EU).  The ACCEPT (AERIUS Control: Clinical and Epidemiological Profile of Tablets) trials will evaluate the efficacy, impact on quality of life, productivity, and pharmacoeconomics of AERIUS in patients with persistent allergic rhinitis (PER) (symptoms lasting four days or more per week and more than four weeks per year) or intermittent allergic rhinitis (IAR) (symptoms lasting less than four days per week or less than four weeks per year).  The trials will be conducted in collaboration with the Global Allergy and Asthma European Network (GA2LEN), a clinical research network of leading European research teams from 16 countries. 

            "The ACCEPT trials are the first multinational studies to involve many of our GA2LEN sites," said Paul Van Cauwenberge, Vice-Chancellor, Ghent University, Belgium and Coordinator of GA2LEN.  "This is a unique collaboration between researchers and industry.  We are pleased to be involved and look forward to expanding our knowledge of managing allergic rhinitis and building an important research partnership with Schering-Plough."             The launch of these trials coincides with the publication of the updated "Allergic Rhinitis and its Impact on Asthma" (ARIA) guidelines, developed by the World Health Organization. 

            Allergic rhinitis has traditionally been classified as seasonal or perennial based on the time of exposure and the nature of the allergen (outdoor or indoor).  According to the updated ARIA guidelines, allergic rhinitis also can be classified as intermittent (IAR) or persistent (PER), based on the duration of the condition rather than the exposure to a seasonal or perennial allergen.  The ACCEPT trials are among the first studies to evaluate an antihistamine based on the ARIA guidelines' classification of allergic rhinitis.

            The ACCEPT trials will involve more than 1,300 patients at nearly 100 sites in 13 countries, and are estimated to be completed in the spring of 2007.              "The ACCEPT trials are landmark studies which will help harmonize standards in the diagnosis and treatment of allergic rhinitis throughout Europe," said Torsten Zuberbier, MD Professor of Dermatology and Allergy, University of Berlin, and lead investigator on the ACCEPT studies.  "These studies will examine practical use of the new ARIA guidelines and evaluate the impact of treatment with desloratadine for patients with intermittent allergic rhinitis or persistent allergic rhinitis."

            The European Medicines Agency (EMEA) has adopted changes to the European Union (EU) label for AERIUS.  AERIUS is now approved for use in IAR and PER and the terms have been added to the Posology and method of administration section (4.2) and the Pharmacodynamic properties section (5.1) of the AERIUS Summary of Product Characteristics (SPC). 

            "Many patients are affected by both seasonal and perennial allergens.  The updated ARIA guidelines and the additional classifications of allergic rhinitis will help physicians more accurately assess and treat their patients' symptoms," said David Price, MD Professor, University of Aberdeen. 

About Allergic Rhinitis

As many as 94 million people across Europe are affected by allergic rhinitis (or hay fever) each year. 1   Symptoms may include sneezing, congestion, runny nose, and itchy or watery eyes.2 

            Symptoms of allergic rhinitis can have an impact on everyday activities at work, school and leisure time.  There also is a growing body of evidence that points to an association between allergies and more serious conditions, such as asthma.

            Survey data show that symptoms are most severe in the morning, and about two-thirds of respondents reported that morning suffering affects the rest of the day.3  Mornings can be an especially difficult time for all allergy sufferers in terms of allergic triggers because pollen concentrations are usually highest between 5 a.m. and 10 a.m.  In addition, if a pet is sleeping in the bed, exposure to their dander during the night may account for the increased prevalence and severity of morning allergy symptoms.  People with allergies also should shower before going to bed to rinse off any pollen or pet dander that may have collected in their hair or on their body during the day.

The survey also showed that even though allergies are frequently a self-diagnosed condition, patients rely on medical experts to help properly manage their symptoms.3


            According to the new classification of the labeling, AERIUS Tablets and AERIUS Syrup is now approved to treat symptoms of allergic rhinitis (including intermittent and persistent allergic rhinitis), in patients 12 years of age and older and patients 1 year of age and older, respectively.

AERIUS (desloratadine) is a nonsedating prescription antihistamine for the treatment of symptoms associated with allergic rhinitis (including intermittent and persistent allergic rhinitis) and chronic idiopathic urticaria (CIU), or hives of unknown cause. AERIUS is available in two convenient forms.  In the European Union, AERIUS Tablets are available for adults and adolescents 12 years of age and older and AERIUS Syrup is available for children as young as 1 year of age.4

Research shows AERIUS provides powerful morning symptom relief.  In a study of 346 people with moderate-to-severe seasonal allergic rhinitis, patients receiving AERIUS experienced significant improvement in morning scores versus placebo for both nasal and non-nasal symptoms.5  AERIUS, which has a 27-hour half-life, offers demonstrated efficacy at the end of the dosing interval.

The most common side effects in adults and adolescents with allergic rhinitis and CIU were fatigue, dry mouth and headache. In infants and toddlers aged 6 to 23 months who received AERIUS Syrup, the most frequent adverse events reported in excess of placebo were diarrhoea, fever and insomnia.  

About Schering-Plough Corporation

            Schering-Plough is a global science-based health care company with leading prescription, consumer and animal health products. Through internal research and collaborations with partners, Schering-Plough discovers, develops, manufactures and markets advanced drug therapies to meet important medical needs. Schering-Plough's vision is to earn the trust of the physicians, patients and customers served by its more than 32,000 people around the world. The company is based in Kenilworth, N.J., and its Web site is

SCHERING-PLOUGH DISCLOSURE NOTICE:  The information in this press release includes certain "forward-looking statements" within the meaning of the Securities Litigation Reform Act of 1995, including statements relating to AERIUS and the potential market for AERIUS.  Forward-looking statements relate to expectations or forecasts of future events.  Schering-Plough does not assume the obligation to update any forward-looking statement.  Many factors could cause actual results to differ materially from Schering-Plough's forward-looking statements, including market forces, economic factors, product availability, patent and other intellectual property protection, current and future branded, generic or over-the-counter competition, the regulatory process, and any developments following regulatory approval, among other uncertainties.  For further details about these and other factors that may impact the forward-looking statements, see Schering-Plough's Securities and Exchange Commission filings, including Item 1A. Risk Factors in the Company's second quarter 2006 10-Q.

# # # References: 
1.  Statistics for Northern, Western, Central, Eastern, Southwestern, Southern and Southeastern Europe combined.
2. Management of Allergic Rhinitis and Its Impact on Asthma: Pocket Guide. 2001.
3. "Understanding the Dynamics Surrounding Allergy Suffering and Treatment" Forbes Consulting Group. 2005.
4. AERIUS (summary of product characteristics)  Schering Corporation.
5. Meltzer EO, Prenner MB, Nayak A, and the Desloratadine Study Group.  Efficacy and tolerability of once-daily 5mg desloratadine, and H1-receptor antagonist, in patients with seasonal allergic rhinitis: assessment during the spring and fall allergy seasons. Clin Drug Invest.  2001; 21:25-32.

Nippon Paper Begins Test Farming Rice That Alleviates Hay Fever

Nippon Paper Group has started test farming a rice which could alleviate hay-fever symptoms. The rice was specially developed using the MAT vector system, a biotechnology for genetically extracting certain genomes, in this case an epitope in the rice. The epitope will act as a vaccine for hay-fever, so people who eat it will experience fewer hay-fever symptoms when the season arrives.

Nippon Paper will set up a large greenhouse of 500 square meters on the island of Komatsu. With proper light and temperature control, the greenhouse will yield 700 kilograms of rice annually.

The project was commissioned by the Ministry of Agriculture, Forestry, and Fisheries.

By Chris Lui, JCN Staff Writer

Copyright © 2006 JCN. All rights reserved. A division of Japan Corporate News Network KK.


The Allergens And Irritants Behind Itchy Skin

What could be the reason for skin that's inflamed, itchy, dotted with bumps or blisters?

According to the September issue of Mayo Clinic Women's HealthSource, it could be contact dermatitis, caused by exposure to an allergen or simply something that irritates the skin.

Irritants can include soaps and detergents. Even plain water can irritate skin with frequent hand washing.

If the culprit is an allergy, the skin doesn't usually react to the first exposure. It can take many exposures for the skin to become sensitive. So, your favorite earrings could be causing the problem. The most common allergens are nickel, a metal commonly used in jewelry, buttons, hooks and zippers; and gold, a precious metal used in jewelry.

Both allergic and irritant contact dermatitis may appear on your hands. But allergic contact dermatitis -- along with other skin conditions such as psoriasis -- may be suspected if you develop a rash on your scalp, neck, earlobes, eyelids, lips or underarms.

Your primary doctor or a dermatologist often can base a diagnosis on your skin's appearance and your recent history of contact with allergens and irritants. If no allergen or irritant is apparent, and your symptoms become chronic, patch testing may be advised. In this procedure, small amounts of different allergens are applied, usually to your back to see how your skin reacts.

Identifying and avoiding an allergen or irritant is the primary treatment. Topical creams containing hydrocortisone or a wet dressing also may be recommended to relieve redness, itching and discomfort. Oral medications may be needed for severe reactions.

Don't expect overnight results. Even with strict allergen or irritant avoidance, contact dermatitis may take weeks or months to clear up.

Mayo Clinic

200 First St. SW
Rochester, MN 55902
United States

April 16, 2007

Colorado Company To Sell Medical Food Products Based On Wake Forest Discovery

A Colorado-based company is launching a line of "medical- food" products for the dietary management of asthma, eczema and other allergic conditions based on discoveries by Floyd H. "Ski" Chilton, Ph.D., of Wake Forest University Health Sciences (WFUHS).

Chilton's discoveries originally led to the founding of a company called Pilot Therapeutics. Now Pilot Therapeutics and WFUHS have licensed rights to the technology to Efficas Inc. of Boulder, Colo., to allow Efficas to produce and market the therapeutic products, said Michael A. Batalia, Ph.D., director of the Office of Technology Asset Management at Wake Forest.

The EfficasTM Care products are aimed at three health conditions: asthma, eczema and allergy. The Efficas Care line is now available for online purchase.

Research by Chilton, professor of physiology and pharmacology at Wake Forest University School of Medicine, focuses on the role that diet or medical foods play in human disease. As the founder of Pilot Therapeutics, he developed an over-the-counter medical food designed to reduce the production of leukotrienes, substances known to play a significant role in asthma and allergy attacks.

"Through our research and clinical trials, we have learned that allergic individuals have a unique dietary need for two fatty acids, GLA (gamma-linolenic acid) and EPA (eicosapentaenoic acid)," Chilton said. "Our studies also show that increased consumption of these nutrients can inhibit leukotriene production in patients."

The new products contain a patented formula of marine oil and botanical oil (borage seed oil) that contains the optimal amount and ratio of GLA and EPA.

"The new licensing arrangement between Efficas, WFUHS and Pilot Therapeutics will allow both companies to advance new technology," Batalia said. "Efficas is a well-funded health science and technology development company with the resources to market these new products, and Pilot Therapeutics now can move on to other product developments."

Besides founding Pilot Therapeutics, Chilton is also director of a WFUHS research program studying dietary supplements, one of five in the country. The program is supported by a $7.5 million grant from the National Center for Complementary and Alternative Medicine and the Office of Dietary Supplements.

The Wake Forest program is a partnership with Brigham and Women's Hospital in Boston and is known as the Wake Forest and Brigham and Women's Program for Botanical Lipids. Botanicals are plant-based dietary ingredients. One of the four main research projects focuses on how borage, marine and echium oils reduce inflammatory messengers that cause diseases such as asthma and arthritis. (Echium oil is a natural vegetable oil rich in short-chain omega-3 polyunsaturated fatty acids that are converted by humans to the fat equivalent of fish oil.)

Efficas, Inc. is a Boulder-based health science and technology development company "committed to developing science-based products for the nutritional management of the immune system both for humans and pets," according to a company news release.

Efficas has received funding from Life Science Partners BioVentures, Burrill and Company, Great Spirit Ventures, Unilever Technology Ventures, JP Morgan Bay Area Equity Fund and Prolog Ventures

"Immune-related conditions affect millions of people and we believe leukotriene-inhibiting technology holds great promise for improved quality of life for these individuals," said Mark Braman, chief executive officer of Efficas.

"Marketing first via the Web allows us to efficiently reach out to the millions of proactive consumers who are seeking information and alternative treatments online," Braman said. "We will follow with specialty and natural retail distribution, then mass retail distribution to make our products more easily accessible to the broader population."


Wake Forest University Baptist Medical Center is an academic health system comprised of North Carolina Baptist Hospital and Wake Forest University Health Sciences, which operates the university's School of Medicine and its other related enterprises including the Piedmont Triad Research Park. The Medical School is ranked 4th in the Southeastern United States in revenues from its licensed intellectual property.

Contact: Robert Conn
Wake Forest University Baptist Medical Center

1st International Study Group For New 'Movement' Discipline

Movement ecology is on the move, with the world's first international research group on this topic having begun its work this fall at the Hebrew University of Jerusalem's Institute for Advanced Studies

Movement ecology is a developing academic pursuit, combining expertise in a variety of fields, including biology, ecology, botany, environmental science, physics, mathematics, virology and others.

It has been largely developed by a Hebrew University of Jerusalem researcher, Prof. Ran Nathan, who heads the Movement Ecology Laboratory in the Department of Evolution, Systematics and Ecology at the university's Alexander Silberman Institute of Life Sciences.. It involves the study of how plant and animal matter travels from one place to another, sometimes for great distances and in highly surprising ways.

The research group now at work at the Hebrew University's Institute for Advanced Studies was convened at the initiative and under the leadership of Prof. Nathan and includes participants from the University of California at Berkeley, the University of California at Davis, Princeton University, Stony Brook University and Rutgers University, all from the U.S.; the Spanish Research Council; and from the Hebrew University, Ben-Gurion University of the Negev and the Technion - Israel Institute of Technology.

Prof. Nathan emphasizes that organism movement research is central to the understanding of how ecological systems work and has important implications for human life. A comprehensive understanding of movement as a process will help to conserve biodiversity, adapt to changes produced by global warming, and cope with environmental threats such as infectious diseases, invasive alien species, agricultural pests and the spread of allergens.

The field of movement ecology and Prof. Nathan were given a large boost of recognition in a recent special issue of Science magazine on migration and dispersal. The issue included an article by Prof. Ran Nathan on his specialty of long-distance dispersal of plants.

In addition, the same issue contained a news article which largely focused on the work of Nathan and his students, as well as others in the U.S., Britain and Australia, focusing on dispersal of both plants and animals.

The article noted that researchers have sought, for centuries, "to understand when, why and how various species crawl, swim, fly, float or hoof it to new locales. That work has led to maps of migration routes and details about dispersals."

"But," the article quoted Prof. Nathan as saying, "few biologists have tried to fit those data into a big picture of movement in general." Now, said the article, through the new discipline called movement ecology, Nathan and others "are beginning to derive testable hypotheses about the mobile behaviors of animals, microbes and even the seeds of plants. Their goal is to join empirical work to theories and to build models that fill in gaps in our understanding of movement -- be it over millimeters or continents or by groups of individuals - in the natural world."

Last year, Nathan was chosen as the winner of the Hebrew University President's Prize for the Outstanding Young Researcher for his pioneering work on seed dispersal. In May this year he was awarded the prestigious Wilhelm Bessel Research Award from the Humboldt Foundation of Germany.


Contact: Jerry Barach
The Hebrew University of Jerusalem

China Biopharmaceuticals Holdings Completes All Clinical Trials Of Desloratadine For Hay Fever

China Biopharmaceuticals Holdings, Inc. (OTC Bulletin Board: CHBP), a leading Chinese pharmaceutical company focused on the development, manufacturing and marketing of innovative drugs in China, today announced the completion of all required clinical trials for Desloratadine tablets for seasonal allergic rhinitis, also known as hay fever. The trials were conducted in six hospitals throughout China. The trial results have been sent to the Chinese State Food and Drug Administration (SFDA) for manufacturing and marketing approval. The Company anticipates an approval response from the SFDA in the second half of 2007.

Desloratadine is indicated for the relief of the nasal and non-nasal symptoms of seasonal allergic rhinitis. It is also indicated for the symptomatic relief of pruritus and the reduction in the number of hives, and size of hives, in patients with chronic idiopathic urticaria. In China, 30% of the population has suffered from an allergy at least once. The $1.5 billion allergy drug market in China continues to grow at a rate of 15% per year.

CHBP President and Chief Operating Officer Lufan An said, "We are pleased to have completed all the required clinical trials for Desloratadine for the SFDA's review. We hope to have the SFDA's approval to manufacture and market this drug by the end of 2007. If we are granted production approval, CHBP will be one of only four pharmaceutical companies producing Desloratadine tablets in China through 2010. This is the latest accomplishment of our R&D team which has submitted 15 drug applications to the SFDA during this calendar year."

In a separate release, CHBP also announced today that it is one of only three companies that received authorization from the SFDA to initiate clinical trials to evaluate the safety and efficacy of Sofalcone for the treatment of digestive ulcers. CHBP also stated that the trials will be conducted in six hospitals throughout China and are expected to be completed within one year.

About China Biopharmaceuticals Holdings

China Biopharmaceuticals Holdings, Inc (CHBP) is a research driven pharmaceutical company dedicated to the discovery, development, manufacturing and marketing of small and large molecule pharmaceutical products, including medicines, vaccines, and active pharmaceutical ingredients for various categories of diseases. CHBP's product portfolio includes 260 drugs already approved for manufacturing and marketing by the Chinese State Food and Drug Administration (SFDA). CHBP also has submitted 15 drug applications to the SFDA for its review during the calendar year of 2006. CHBP is a U.S.-listed public company with operating subsidiaries and senior management based in China. For further information, please visit our website at

Safe Harbor Statement

The statements contained herein that are not historical facts are "forward looking statements" within the meaning of Section 21E of the Securities and Exchange Act of 1934, as amended, and the Private Securities Litigation Reform Act of 1995. Such forward-looking statements may be identified by, among other things, the use of forward-looking terminology such as "believes," "expects," "may," "will," "should," or "anticipates" or the negative thereof or other variations thereon or comparable terminology, or by discussions of strategy that involve risks and uncertainties. In particular, our statements regarding the potential growth of the markets are examples of such forward- looking statements. The forward-looking statements include risks and uncertainties, including but not limited to, general economic conditions and regulatory developments, not within our control. The factors discussed herein and expressed from time to time in our filings with the Securities and Exchange Commission could cause actual results and developments to be materially different from those expressed or implied by such statements. The forward looking statements are made only as of the date of this filing, and we undertake no obligation to publicly update such forward-looking statements to reflect subsequent events or circumstances.

China Biopharmaceuticals Holdings, Inc.

Diet May Help Prevent Allergies And Asthma

A recent publication from the Global Allergy and Asthma European Network (GA2LEN) (1) provides new insights into the role that diet may play in the development of allergies, especially in children. The work suggests that the significant changes in European diets over the past 20-40 years may have contributed to the increased incidence of allergic diseases in both children and adults seen over this period. Members of the nutrition work package responsible for the report consider that its findings are just the beginning of GA2LEN's potential role in greater understanding of this complex area.

The prevalence of allergic diseases has increased dramatically over the past few decades, especially in children. One child in three is allergic today and one in two people in Europe are likely to be suffering from at least one allergy by 2015. It is generally agreed that a combination of heredity and environmental factors is responsible for the development of the allergy and asthma. However, the evolution of these diseases has been far too rapid for genetics to be the sole explanation. Among the wide range of environmental factors under discussion, changes in the European diet in the last 20-40 years are considered to be a possible explanation. Indeed, the way in which children are fed early in life may have a direct effect on the subsequent development of asthma and allergies, according to a recent publication from the Global Allergy and Asthma European Network (GA2LEN). (1)

In a paper entitled "Nutrition and allergic disease", published this year in Clinical and Experimental Allergy Reviews, 12 European experts working together in the GA2LEN nutrition work package present the evidence and define fertile topics for future research. (2) The work package team is led by Professor Philip C Calder, Institute of Human Nutrition, University of Southampton. (3)

Key findings: breastfeeding, early diet and probiotics

The three main areas producing key findings are breastfeeding, intake of certain nutrients, and probiotics. (4)

Exclusive breastfeeding, that is providing the infant with no other liquid or food other than breast milk, is believed to be effective in reducing subsequent development of allergies. It appears that exclusive breastfeeding for four months helps protect the child from cow's milk protein allergy until 18 months, reduces the likelihood of dermatitis (skin allergy) until three years, and reduces the risk of recurrent wheeze (or asthma) until six years' of age. However, the longer term effects of breast feeding on allergic outcomes are not known and require investigation.

The protective effect of four months of exclusive breastfeeding is important for all children but it is especially valuable for those at high risk of developing allergies. Children are at high risk of developing allergies if one or both parents are affected by allergic disease. If it is not possible for the high-risk child to be breastfed, hypoallergenic formula combined with avoidance of solid foods for 4-6 months offers an alternative source of protection. The studies show that hypoallergenic formula helps prevent cows' milk protein allergy developing before the age of five years and offers protection against atopic dermatitis (eczema or other skin allergy) until the age of four years.

A second major area of importance appears to be the components of the diet. For example, antioxidants in the diet, such as vitamin C, vitamin E and selenium coming mainly from fruit and vegetables, may have a protective effect. Furthermore, different fats found in milk, butter, vegetable oils and fish may have different effects on development of allergies and asthma. Although it is difficult to find clear-cut evidence, it appears that reducing sodium intake, increasing magnesium intake, eating apples and other fruit and vegetables, and avoiding margarine might help some asthmatics. However much of the research conducted to date has not been systematic in its approach and this makes the drawing of hard conclusions very difficult.

The role of probiotics and prebiotics in the diet is promising. Living organisms such as probiotics appear to protect against the development of allergies by producing changes in the bacteria in the gut that stimulate the immune system. A double blind, placebo-controlled study has recently shown that probiotics can help reduce the risk of atopic disease. This is an important area for future research.

Meeting the challenge

The review highlighted several areas in nutrition and diet that appear to be fruitful for future research in allergic disease, and therefore for future disease control. In particular, it has highlighted gaps in relation to specific effects of maternal and infant nutrition on allergy and asthma in later life. Patients, health professionals and policy makers alike would benefit from such research and from more large-scale studies on diet and allergy. Key focuses should be identification of dietary patterns or factors likely to be involved in altering risk of development of allergies and asthma, and developing the evidence base about whether supplementation with specific fats or probiotics could contribute both to the protection and treatment of allergic diseases. The studies required will need to be large and to be well planned, designed and executed. They are likely to require cross-country collaboration.



1. GA2LEN - the Global Allergy and Asthma European Network is a "Network of Excellence" funded by the European Union 6th Research Framework Programme. It consists of 26 research centres spread throughout Europe, as well as the European Academy of Allergology and Clinical Immunology (EAACI) and the European Federation of Allergy and Airways Diseases Patients Associations (EFA).

2. The 72-page peer-reviewed paper entitled "Nutrition and allergic disease" is published in Clinical and Experimental Allergy Reviews 6: 117-188, 2006 Blackwell Publishing Ltd.

3. The article represents the work of Workpackage 2.1 of GA2LEN. Correspondence should be addressed to the workpackage leader, P. C. Calder, BSc, PhD, DPhil, Professor of Nutritional Immunology, Institute of Nutrition, University of Southampton, UK.

4. The full list of indicators comprises: Sodium and potassium, magnesium, lipids including fatty acids in milk, butter, vegetable oils and fish, antioxidants, including fruit and vegetable intake, flavonoids and flavonoid-rich foods, Vitamin C, Vitamin E, b-Carotene, Vitamin A, selenium, zinc and copper, and probiotics and prebiotics.


P.C. Calder
Institute of Human Nutrition
School of Medicine
University of Southampton
Bassett Crescent East
Southampton SO16 7PX

GA2LEN Dissemination
Avenue Brugmann 151
B-1190 Brussels
Noelie Auvergne

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